Liver cirrhosis is a common ailment afflicting a significant proportion of Pakistani population of all ages.Quite often, these patients require multi-system intervention, owing to the nature of this disease.This study was specifically conceived to objectively assess the level of thyroid dysfunction in cirrhotics of the urban population of Karachi,
ObjectivesThe cabin-skeleton coupling structure of a blended-wing-body underwater glider is optimized using a data-driven discrete optimization concept.MethodsFirst, a Kriging-assisted discrete global optimization algorithm (KDGO) is proposed for computationally expensive black-box problems.The KDGO uses a novel infill-sampling strategy to capture
We examined influence of the β-amyloid peptide (25-35) neurotoxic fragment (βAP) on Helix lucorum food-aversion learning.Testing with aversively conditioned carrot showed that 2, Sweeper 5, and 14 days after training the βAP-injected group responded in a significantly larger number of cases and with a significantly smaller latency th
Editorial summary Inhibitors of poly(ADP-ribose) polymerase (PARPi) have entered the clinic for the treatment of patients with cancers that lack homology-directed Used Goal Skates DNA repair, but drug resistance remains a clinical hurdle.Recent advances in the identification of VESTS SUIT PARPi resistance mechanisms have yielded a better understand